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Data Mining and Multivariate Analysis

Project description

The activities in this project involved two Diploma projects (Christina Johansson, summer/fall 1998 and Mikael Nordström, summer/fall 1999), and 20% work by Stefan Arnborg.

The first Diploma project [1] involved assessment of computational and statistical methods for handling image information, and a study of the capabilities of the CBA program (developed by Lennart Thurfjell, Uppsala) on a set of SPECT/MR images that were obtained from other ongoing investigations.

The second Diploma project [2] involved investigating segmentation methods by anisotropic diffusion, using the GOP method (Context Vision, Linköping), SPM (Wellcome, London), AIR (UCLA), and BRAINS (University of Iowa).
A practical result of the second project has been the definition of a Workup adapted from the University of Iowa (MHRC) workup, with the BRAINS and AIR programs [3].

This workup is described under the Brain Morphology project. A current activity in brain imaging is development, by doctoral student Roger Hult, Uppsala University, of improved segmentation in the BRAINS II software and automated co-registration of post-mortem brain slice images obtained by cryosectioning methods.

- Christina Johansson: Extraction of information from medical images, BSc Diploma project.
- Mikael Nordström: Segmentation of brain into tissue types from MR. MScE Diploma project, SICS TR.
- Harris, Andreassen, Cizardo, Bailey, Bockholt, Magnotta, Arndt: Improving tissue segmentation in magnetic resonance imaging: A multispectral supervised discriminant analysis method with automated training class selection. Mental Health Clinical Research Center, the University of Iowa College of Medicine and Hospitals and Clinics.
- Arndt, Woolson: Establishing a biostatistical core unit in a clinical research center. The American Statistician 45(1), Feb 1991.

Project leader: Stefan Arnborg
Participants: Cab Mert and Glenn Lawyer

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Håkan Hall and Ulrika Kahl at Human Brain Informatics
Department of Clinical Neuroscience, Psychiatry Section
Karolinska Institutet, SE-171 76 Stockholm, SWEDEN.
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