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Analyzing DNA from patients and controls

DNA from patients and controls
The aim of this project is to develop a micro array-based method enabling the analysis of thousands of SNPs. By analyzing DNA from patients and controls, the researchers hope to find susceptibility genes that could be used as drug targets and for diagnosis of schizophrenia. For each individual, approximately 100 SNPs will be analyzed.

The numbers game
To get a feeling for the possible complexity, consider 13 genes each in three possible variants. That number alone keeps many people queuing weekly in filling out a football pools coupon.

The future
Calculation of associations will be conducted for a large number of candidate genes. New interesting candidate genes will be added to the list, and potential candidate genes for mutations will be sequenced.

 

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© HUBIN updated September 26, 2002 .

Håkan Hall and Ulrika Kahl at Human Brain Informatics
Department of Clinical Neuroscience, Psychiatry Section
Karolinska Institutet, SE-171 76 Stockholm, SWEDEN.
Phone: +46-8-517 75651 Fax: +46-8-34 65 63 E-mail: info@hubin.org