The future
The material collected in the HUBIN consortium
can continuously be expanded with interviews and blood-sample collection
from patients, relatives and controls. Clinical subcategories will
be searched for, using the different clinical data sets and multivariate
statistical and data mining methods.
Within this project and previous similar
studies, DNA and clinical phenotypic data are so far available for
ca. 250 schizophrenic patients and a similar number of healthy controls.
Polymorphisms for a number of candidate genes will be examined in
relation to psychopathology and brain imaging data. The aim is to
obtain DNA and interviews for about 160 subjects every year.
When a sufficient sample size has been obtained
(i.e. more than 700 subjects), DNA will be further analyzed with
regard to polymorphisms for up to 10 000 putative candidate genes
using array techniques, developed within a HUBIN method development
project.
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