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Erik G. Jönsson
M.D., Ph.D. Consultant,
Dept. of Psychiatry,
Karolinska Hospital
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Address:
Visiting address:
Psykiatriska kliniken R5:00
Karolinska sjukhuset
SE-171 76 Stockholm
Mailing address:
Department of Clinical Neuroscience
Psychiatry Section
Karolinska Institute
SE-171 76 Stockholm
Sweden
Telephone:
+46-8-517 72626
Fax:
+46-8-34 65 63
E-mail:
erikj@ks.se
Education:
- M.D., University of Uppsala 1979
- Licence to practice medicine, Jönköping 1983
- Certified specialist in psychiatry, Karolinska Hospital 1988
- Ph.D., Karolinska Institute 1997
Professional experience:
- Internship, General hospital in Jönköping,
1981-1983
- Specialist training, residency, Dept. of Psychiatry, Karolinska
hospital, 1983Đ1988
- Consultant, Dept. of Psychiatry, Karolinska hospital, 1988-present
Memberships:
- The Swedish Medical Association,
1981-
- The Swedish Psychiatric Association, 1989-
- Svenska Sällskapet fšr Medicinsk Genetik, 1992-
- International Society for Psychiatric Genetics (ISPG), 1994-
- American Society of Human Genetics (ASHG), 1997-
- Svenska schizofrenisällskapet, 1998-
Stipends, honors
and awards:
- Fellowship, Ulf Lundahls Memory Foundation,
1990 -1992
Brief description
of present research:
Genetic factors have been implicated in the
pathophysiology of schizophrenia. With the advent of molecular genetic
techniques it has been possible to investigate differences in the
genome to elucidate the genetic contributions to the disease. In
complex disorders, such as schizophrenia, which result from the
interaction of various vulnerability genes and non genetic factors,
association studies are the most efficient strategy to explore the
putative contribution at candidate gene loci. From previous research,
a number of potential candidate genes are suggested, e.g. genes
involved in the dopamine transmission and neurodevelopment of the
brain. With the rapid technical development it will also probably
soon be possible to make a genome screen also on association materials.
Patients with schizophrenia, their parents and non-related control
subjects will be investigated with a personal structural psychiatric
interview. Hospital records will be examined for diagnoses. Patients
with schizophrenia will be analysed versus control subjects with
regard to potential candidate genes. When techniques have evolved
the material will also be analysed with a genome screen. This research
may give help in identifying genes contributing to schizophrenia.
 Click
here
for moer information about Erik Jönsson's research project
Selected references:
- Jönsson EG, Nöthen MM,
Gustavsson JP, Neidt H, Bunzel R, Propping P, Sedvall GC (1998)
Polymorphisms in the dopamine-, serotonin-, and norepinephrine transporter
genes and their relationships to monoamine metabolite concentrations
in CSF of healthy volunteers. Psychiatry Research 79, 1-9.
- Gustavsson JP, Nšthen MM, Jönsson EG, Neidt H, Forslund K,
Rylander G, Mattila-Eveden M, Sedvall GC, Propping P, Åsberg
M (1999) No association between serotonin transporter gene polymorphisms
and personality traits. American Journal of Medical Genetics 88,
430-436.
- Jönsson EG, Nimgaonkar VL, Zhang XR, Shaw SH, Burgert E,
Crocq M-A, Chakravarti A, Sedvall GC (1999) Trend for an association
between schizophrenia and D3S1310, a marker in proximity to the
dopamine D3 receptor gene. American Journal of Medical Genetics
88, 352-357.
- Jšnsson EG, Nöthen MM, Grünhage F, Farde L, Nakashima
Y, Propping P, Sedvall GC (1999) Polymorphisms in the dopamine D2
receptor gene and their relationships to striatal dopamine receptor
density of healthy volunteers. Molecular Psychiatry 4, 290-296.
- Jönsson EG, Nšthen MM, Neidt H, Forslund K, Rylander G, Mattila-Evenden
M, Åsberg M, Propping P, Sedvall GC (1999) Association between
a promoter polymorphism in the dopamine D2 receptor gene and schizophrenia.
Schizophrenia Research 40, 31-36.
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