Göran Sedvall Professor of Psychiatry

Address:
Mailing address:
Department of Clinical Neuroscience
Section of Psychiatry Karolinska Hospital
SE-171 76 Stockholm
Sweden

Visiting:
Karolinska Hospital Psychiatric Clinic

Telephone:
+46-8-5177 44 45 (work)
+46-70-638 48 40 (cell phone)

Fax:
+46-8-517 71717

E-mail:
goran.sedvall@ks.se

Education:
- Bach. Med., Karolinska Institutet, Stockholm, Sweden, 1957
- Lic Med., Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden, 1965
- M.D., Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden, 1965

Professional experience:
- Postdoctoral Fellow, Lab Clinical Science (Dr I.J. Kopin), National Institute of Mental Health, Bethesda, MD, USA, 1965-66
- Assistant Professor of Pharmacology, Karolinska Institutet, Stockholm, Sweden, 1965-70
- Assistant Professor of Psychiatry, Karolinska Institutet, Stockholm, Sweden, 1970-71
- Associate Professor of Neuropsychopharmacology, Karolinska Institutet, Stockholm, Sweden, 1971-75
- Associate Professor of Experimental Psychiatry, Karolinska Institutet, Stockholm, Sweden, 1975-80
- Prefect, Department of Psychiatry, Karolinska Institutet and Hospital, Stockholm, Sweden, 1980-85
- Visiting Professor, Laboratory of Molecular and Cellular Neuroscience (Professor P. Greengard), Rockefeller University, New York, NY, 1984-85
- Director Psychiatric Clinic, Karolinska Hospital, Stockholm, Sweden, 1980-99
- Professor of Psychiatry, Karolinska Institutet, 1980-present

Special Appointments:
- Member Nobel Assembly, Karolinska Institutet, 1984
- Member, Scientific Advisory Board, Swedish Board of Health and Welfare, - Stockholm, Sweden, 1984
- Council Member, European Association of Psychiatrists, EAP, 1988 Council - Member, Collegium Internationale Neuropsychopharmacologicum, CINP, 1988
- Chairman, Awards Committee, CINP, 1995
- Chairman, Nobel Assembly, Karolinska Institutet, Stockholm, Sweden, 1997
- Foreign Associate Member, Institutet of Medicine, National Academy of Science, Washington, DC, 1998
- Vice President CINP (Collegium Internationale Neuropsychopharmacologicum), 1998
- President Elect of the AEP (Association of European Psychiatrists), 1999

Memberships:
- Professional Jourrnal Activity: Member Nobel Assembly, Karolinska Institutet, 1988
- Member, Scientific Advisory Board, Swedish Board of Health and Welfare, - Stockholm, Sweden, 1984
- Council Member, European Association of Psychiatrists, EAP, 1988
- Council Member, Collegium Internationale Neuropsychopharmacologicum, CINP, 1988
- Chairman, Awards Committee, CINP, 1995
- Chairman, Nobel Assembly, Karolinska Institutet, Stockholm, Sweden, 1997
- Foreign Associate Member, Institutet of Medicine, National Academy of Science, Washington, DC, 1998
- Vice President CINP (Collegium Internationale Neuropsychopharmacologicum), 1998
- President Elect of the AEP (Association of European Psychiatrists), 1999
- Member of scientific Societies: Member, Scandinavian Society for Neuropsychopharmacology, 1965
- Member, Scandinavian Society for Biological Psychiatry, 1978
- Foreign Corresponding Member, American College of Neuropsychopharmacology, 1982
- Foreign Corresponding Member, Deutsche Gesellschaft fŸr Psychiatrie und Nervenheilkunde, 1988
- Member, European Association of Psychiatrists, EAP, 1988
Member, Collegium Internationale Neuropsychopharmacologicum, CINP, 1988
- Member, World Psychiatric Association, WPA, 1991
- Member, American Association for the Advancement of Science, 1993
- Corresponding Member, International Academy for Biomedical and Drug Research, 1996

Stipends, honors and awards:
- Roerig-Pfizer Visiting Scientist Award, 1987
- Past John Flynn Memorial Award, Yale University, New Haven, 1987
- Merit Award, NIMH, 1988
- The Wyeth-Ayerst Award for Distinction in Psychiatry, WPA, Athens, Greece, 1989
- Esteemed Fifth Dr Robert K. Match Distinguished Scholar, LIJMS, New York, 1990
- The Eli Lilly Award, ECNP, Jerusalem, 1994
- NARSAD Research Lieber Prize, New York, 1997
- The Ingvar Prize in Clinical Neuroscience, Swedish Society of Medicine, 1998

Brief description of present research:
Göran SedvallÕs research interest and activities have a focus on the ethiology and pathophysiology of schizophrenia and bipolar affective psychoses. He is currently the principal investigator of several clinical research programs in local and national patient populations exploring molecular genetic and environmental influences on human brain morphology, biochemistry and gene expression in relation to psychopathological variables. Data from these projects are entered into a clinical relational database allowing the exploration of relationships between the multidimensional data domains examined in these subject populations. This database project called Human Brain Informatics (HUBIN) is expected to accumulate extensive data for about 3.000 schizophrenic patients and a corresponding number of control subjects during the coming five-year period. The database will be used as a tool to explore and test a number of current hypotheses regarding ethiological and pathopsychological mechanisms increasing vulnerability for schizophrenia. Advanced biomathematical and data mining methods will be implemented for this purpose.

Selected references:
- Sedvall G, Farde L, Hall H, Halldin C, Karlsson P, Nordström A-L, Nyberg S, Pauli S: Utilization of radioligands in schizophrenia research. Clin Neuroscie 3:112-121, 1995
- BrenŽ S, Hall H, Lindefors N, Karlsson P, Halldin C, Sedvall G: Distribution of mRNAs for D1 dopamine receptors and DARPP-32 in striatum and cerebral cortex of the cynomolgus monkey. Relationship to D1 dopamine receptors. Neuroscience 67:37-48, 1995
- Sedvall G, Farde L: Chemical brain anatomy in schizophrenia. Lancet 346:743-749, 1995
- Jönsson E, Sedvall G, BrenŽ S, Gustafsson J P, Geijer T, Terenius L, Crocq A, Lannfelt L, Tylec A, Sokoloff P, Schwartz J C, Wiesel F-A: Dopamine-related genes and their relationships to monoamine metabolites in CSF. Biol Psychiatry 40:1032-1043, 1996
- Hall H, Lundkvist C, Halldin C, Farde L, Pike V W, McCarron J A, Fletcher A, Cliffe I A, Barf T, Wikström H, Sedvall G: Autoradiographic localization of 5-HT1A receptors in the post-mortem human brain using [3H]Way-100635 and [11C]Way-100635. Brain Research 745:96-108, 1997
- Pauli S, Sedvall C G: Three dimensional visualization and quantification of the benzodiazepine receptor population within a living human brain using PET and MRI. Eur Arch Psych Clin Neurosci 247:61-70, 1997
- Suzuki M, Hurd Y L, Sokoloff P, Schwartz J-C, Sedvall G: D3 dopamine receptor mRNA is widely expressed in the human brain. Brain Research 779:58-74, 1998
- Jönsson EG, HŠrnryd C, Johannesson T, Wahlström J, Bergenius J, Bergstedt H, Greitz D, Nyman H, Björck E, Blennow E, Sedvall G C: Further studies on a male monozygotic triplet with schizophrenia: cytogenetical and neurobiological assessments in the patients and their parents. Eur Arch Psych Clin Neurosci 247:239-247, 1997
- Hall H, Farde L, Halldin C, Lundkvist C, Sedvall G: Autoradiographic Localization of 5-HT2A Receptors in the Human Brain Using [3H]M100907 and [11C]M100907. Synapse. In press Sedvall GC: Psychosis. In Clin.Pharmacol. Ed.Cesare Sirtori, Publ. McGraw-Hill, Series of Clinical Medicine. 2000. In press.

Apart from the above listed references, Göran C. Sedvall has produced more than 400 scientific publications in international journals. Practically all of these are concerned with biochemical, physiological, pharmacological or psychiatric aspects of the role of the transmitter amines: noradrenaline, dopamine and serotonin.