Håkan Hall Associate Professor, Ph.D.

Address:
Department of Clinical Neuroscience
Psychiatry Section
Karolinska Hospital
SE-17176 Stockholm
Sweden

Telephone:
+46-8-517 74792
+46-8-517 74445 (secretary)
+46-70-484 1292 (cell)

Fax:
+46-8-517 71717

E-mail:
hakan.hall@cns.ki.se

Education:
- Fil. kand. (corresponding to M. Sc.), University of Uppsala 1971
- Ph. D., University of Uppsala 1976.
- Associate professor in Zoophysiology at University of Uppsala 1985
- Associate professor in Neuropsychopharmacology at the Karolinska Institute 1991

Professional experience:
- Visiting scientist at INRA, Station de Physiologie de la Reproduction, Nouzilly, France during 6 months 1974-1975
- Section Head, Astra, 1975-1990
- Scientist, Karolinska Institute, 1990-present
- Visiting scientist at Clarke Institute of Psychiatry, Universtiy of Toronto, Canada during 12 months 1992-1993

Memberships:
- New York Academy of Sciences
- European Association of Neuroscience
- European Society of Neuropsychopharmacology
- Svenska Läkaresällskapets Sektion för Läkemedelslära

Stipends, honors and awards:
- Marie Curie Award at European Association of Nuclear Medicine 1992

Brief description of present research:
Studies on the receptor effects of neuroactive drugs, mainly using in vitro receptor binding assay and radioligand autoradiography. The research has mostly dealt with development of new neuroleptic drugs and radioligands (at Astra) and presently the distribution of dopamine and serotonin receptor subtypes in the post-mortem human brain. Using in vitro ligand autoradiography on human whole hemisphere brain sections, the distribution of various receptor subtypes and transporter proteins are investigated. Håkan Hall«s main interest is on receptors likely to be involved in psychiatric disorders, such as the dopamine (D1- D2- and D3) and serotonin (5-HT1A, 5-HT1B, 5-HT2A, 5HT2C, and 5HT4) receptor subtypes. Autoradiography is also performed at close intervals making it possible to construct 3D images of the receptor distribution. He is also involved in developing new more selective receptor and transporter radioligands, in collaboration with research groups at the Karolinska Institute and abroad. Collection of brain hemispheres, mainly from deceased patients with schizophrenia, is currently performed aiming at detailed 2D and 3D studies of the receptor distribution in schizophrenia. Håkan Hall is also project leader for the human brain informatics project (HUBIN).

Selected references:
- Hall H, Farde L, Sedvall G. Autoradiographic localization of extra striatal D2-dopamine receptors in the human brain using [125I]epidepride. Synapse, 23;115-123:1996
- Hall H, Halldin C, Dijkstra D, Wikström H, Wise LD, Pugsley TA, Sokoloff P, Farde L, Sedvall G Autoradiographic localization of D3-dopamine receptors in the human brain using the selective D3-dopamine receptor agonist (+)-[3H]PD 128907. Psychopharmacology, 128;1996:240-247
- Litton JE, Hall H, Blomqvist, G. Improved receptor analysis in PET using a priori information from in vitro binding assays. Phys. Med. Biol., 42;1997
- Günther I, Hall H, Halldin C, Swahn C-G, Farde L, Sedvall G. Kinetics and pharmacology of [125I]b-CIT, [125I]b-CIT-FP and [125I]b-CIT-FE. An autoradiography study in the human brain. Nucl. Med. Biol. 24;629-634:1997
- Svenningson P, Hall H, Sedvall G, Fredholm BB. Distribution of adenosine receptors in the post-mortem human brain. An autoradiographic study. Synapse, 27:322-335:1997
- Hall, H., Halldin, C., Guilloteau, D., Chalon, S., Emond, P., Besnard, J.-C., Farde, L., and Sedvall, G. Visualization of the dopamine transporter in the human brain post-mortem with the new selective ligand [125I]PE2I. Neuroimage, 9; 1008 Ð1116 1999
- Tupala, E., Hall, H., Särkioja, T., Räsänen, P., and Tiihonen, J. Dopamine-transporter density in nucleus accumbens of type-1 alcoholics. Lancet, 355(9201):380, 2000. Bonaventure, P., Hall, H., Gommeren, W., Cras, P., - Langlois, X., Jurzak, M., and Leysen, J.E. Mapping of serotonin 5-HT4 receptor mRNA and ligand binding sites in the post-mortem human brain. Synapse, 36(1):35-46, 2000
- Dupuis, D.S., Pauwels, P.J., Radu, D., and Hall, H. Autoradiographic studies of 5-HT1A-receptor-stimulated [35S]GTPgS-binding responses in the human and monkey brain. European Journal of Neuroscience, 11(5):1809-1817, 1999
- Nobuhara, K., Halldin, C., Hall, H., Karlsson, P., Farde, L., Hiltunen, J., McPherson, D.W., Savonen, A., Bergstrom, K.A., Pauli, S., Swahn, C.G., Larsson, S.A., Schnell, P.O., and Sedvall, G. Z-IQNP: a potential radioligand for SPECT imaging of muscarinic acetylcholine receptors in Alzheimer's disease. Psychopharmacology, 149(1):45-55, 2000