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Namn:
Per Karlsson
Titel och nuvarande befattning:
leg. läkare
Adress:
Psykiatricentrum Karolinska
Karolinska sjukhuset
171 76 Stockholm
Telefon:
08-517 72902
0706-303 261
Fax:
08-517 71753
E-mail:
per.karlsson@knv.ki.se
Utbildning:
- Läkarexamen, Karolinska Institutet, 1988
Yrkeserfarenhet:
- Distriktsläkare, Nesbyen, Norge, 1990
- Underläkare Psykiatriska kliniken Karolinska sjukhuset, sedan
1990
- Doktorand Karolinska Institutet, Klin. neurovet, psykiatri sedan
1993
Medlemskap:
- Sveriges läkarförbund, 1988
- Svenska läkaresällskapet, 1988
- European College of Neuropsychopharmacology, 1998
Stipendier och utmärkelser:
- Marie Curie award, 1992
- Young Investigator Award, International Congress on Schizophrenia
Research, 1995
- Winter Workshop on Schizophrenia Research Award, 1996
Kort presentation av nuvarande forskning:
Utveckla radioligander för Positronemissionstomografi (PET)
som binder till D1-dopamin receptorer. Jämföra D1-receptorbindning
(Bmax och Kd) hos friska försökspersoner och nyinsjuknade,
obehandlade patienter med schizofreni. Mäta D1-receptorblockad
i hjärnan hos friska och patienter efter orala doser av selektiva
D1-receptor antagonister och relatera den till plasmakoncetration
och kliniska effekter. Studera dygnsrytmen av D1-receptor bindning
i hjärnan hos friska.
Utvalda referenser:
- Chou YH, Karlsson P, Halldin C, Olsson H, Farde L (1999) A PET
study of D(1)-like dopamine receptor ligand binding during altered
endogenous dopamine levels in the primate brain. Psychopharmacology
146: 220-7
- Halldin C, Foged C, Chou YH, Karlsson P, Swahn CG, Sandell J,
Sedvall G, Farde L (1998) Carbon-11-NNC 112: a radioligand for PET
examination of striatal and neocortical D1-dopamine receptors. Journal
of Nuclear Medicine 39: 2061-8
- Halldin C, Foged C, Karlsson P, Swahn C-G, Andersen PH, Farde
L (1994) [11C]NNC 112, a selective PET radioligand for examination
of extrastriatal dopamine D1 receptors. J Nucl Med 35: 122
- Karlsson P, Farde L (in preparation) Circadian rhythm in central
D1-like dopamine receptors examined by PET.
- Karlsson P, Farde L (submitted) Circadian rhythm in central D1-like
dopamine receptors examined by PET.
- Karlsson P, Farde L, Halldin C, Nordström A, Sedvall G (1993a)
D1 dopamine receptor binding in drug naive schizophrenic patients
measured by PET (Abstract) Cerebral Blood Flood Flow Metabolism,
pp S556
- Karlsson P, Farde L, Halldin C, Sedvall G (1997) D1-dopamine receptors
in schizophrenia examined by PET. Schizophrenia Research 24: 178-79
- Karlsson P, Farde L, Halldin C, Sedvall G (in preparation) D1-
dopamine receptor binding in neuroleptic naive schizophrenic patients
examined by PET.
- Karlsson P, Farde L, Halldin C, Sedvall G, Ynddal L, Slothnielsen
M (1995a) Oral administration of NNC 756 - a placebo controlled
pet study of D1-dopamine receptor occupancy and pharmacodynamics
in man. Psychopharmacology 119: 1-8
- Karlsson P, Farde L, Halldin C, Swahn CG, Sedvall G, Foged C,
Hansen KT, Skrumsager B (1993b) PET examination of [11C]NNC 687
and [11C]NNC 756 as new radioligands for the D1-dopamine receptor.
Psychopharmacology 113: 149-56
- Karlsson P, Sedvall G, Halldin C, Swahn CG, Farde L (1995b) Evaluation
of sch 39166 as pet ligand for central D1 dopamine receptor binding
and occupancy in man. Psychopharmacology 121: 300-308
- Karlsson P, Smith L, Farde L, Harnryd C, Sedvall G, Wiesel FA
(1995c) Lack of apparent antipsychotic effect of the D1-dopamine
receptor antagonist sch39166 in acutely ill schizophrenic patients.
Psychopharmacology 121: 309-316
- Movin-Osswald G, Karlsson P, Hammarlund-Udenaes M, Farde L (1994)
Influence of rate of administration of raclopride on akathisia and
prolactin response. Psychopharmacology 114: 248-56
- Suhara T, Farde L, Halldin C, Nagren K, Karlsson P (1996) Effects
of cocaine on [11C]norepinephrine and [11C] beta-CIT uptake in the
primate peripheral organs measured by PET. Annals of Nuclear Medicine
10: 85-8
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