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Rolf Adolfsson
Professor of Psychiatry
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Address:
Department of clinical
Sciences Psychiatry Section
Umeå University
SE-901 85 Umeå
Telephone:
+46-90-132761
Fax:
+46-90-136196
E-mail:
Rolf.Adolfsson@psychiat.umu.se
Memberships:
- Memberships in The National Schizophrenia
Society
- The Swedish Serotonin Society
- International Society of Psychiatric Genetics
Brief description
of present research:
The focus of our work has been to disclose the basic mechanisms
underlying prevalent mental disorders by integrating clinical, molecular,
biological and environmental approaches. To accomplish this we have
systematically applied our clinical tools on specific patient-groups
(schizophrenia, uni- and bipolar disorders, suicide victims etc)
and on random population samples, to study different phenotypes
from both a categorical and a dimensional view. The strategy of
using random population samples in psychiatric genetic research
is of great importance as this strategy have allowed and will allow
the identification of basic genetic mechanisms i.e. in memory and
personality, which probably will be of great relevance for the study
of psychiatric disorders. A project like this, as emphasized, calls
for specialist knowledge, covering clinical, genetic, biological,
statistical, epidemiological and technological domains. The characterization
and collection of relevant phenotypes are of outmost importance
in our collaborative approaches. This work has resulted in a banking
of approximately 9 000 individuals (of blood, DNA, plasma, serum).
Selected references:
- M, Pettersson U, Adolfsson R, Jazin EE.
Linkage analysis of candidate loci in families with recurrent major
depression. Mol Psychiatry 1998; 2: 162-8.
- Brändström S, , Schlette P, Pryzbeck T, Lundberg M,
Forsgren T, Sigvardsson S, Nylander P-O, Nilsson LG, Cloninger CR,
Adolfsson R. Swedish normative data on personality using the Temperament
and Character Inventory. Comp Psychiatry 1998; 39: 122-128.
- Lindblad K, Nylander PO, Zander C, Yuan QP, Ståhle L, Engström
C, Balciuiene J, Breschel T, McInnis M, Ross CA, Adolfsson R, Schalling
M. Two commonly expanded CAG/CTG repeat loci: Involvement in affective
disorders? Mol Psychiatry 1998; 3: 405-410
- Bejerot S, Schlette P, Ekselius L, Adolfsson R, von Knorring L.
Personality disorders and relationship to personality dimensions
measured by the Temperament and Character Inventory in patients
with Obsessive Compulsive Disorder. Acta psychiatr Scand 1998; 3.
243-9.
- Lindholm E, Ekholm B, Castensson A, Johansson G, Balciuiene J,
Nylander PO, Pettersson U, Adolfsson R, Jazin E. Linkage analysis
of a large Swedish kindred provides further support for a susceptibility
locus for schizophrenia on chromosome 6p23. Mol Psychiatry 1998;
2:162-168
- Schlette P, Brändström S, Eisemann M, Sigvardsson S,Nylander
P-O, Adolfsson R, Perris C. Perceived parental rearing behaviours
and temperament and character in healthy adults. Person Individ
diff 1998; 24: 661-618
- Smedh K, Spigset O, Allard P, Mjörndal T, Adolfsson R. Platelet
3H paroxetine and 3LSD binding in Seasonal affective disorder (SAD)
and the effect of bright light therapy. Biological Psychiatry 1999;
45: 464-470
- Sourey D, Lipp O, Rivelli SK, et al. Tyrosine hydroxylase polymorphism
and phenotypic heterogenity in bipolar affective disorder: A multicenter
association study. Am J Med Gen (Neuropsych Gen) 1999; 88: 527-532
- Lundberg M, Perris C, Adolfsson R. Transcultural influences on
the perception of parental rearing-A transgenerational study. Clinical
Psychology & Psychotherpy; 6: 7-15
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