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Håkan Hall seminar abstract
HUBIN – Human Brain Informatics:
a database project on schizophrenia
H. Hall, T. McNeil, S. Arnborg, L. Terenius
and G. Sedvall
Karolinska Institutet, Department of Clinical
Neuroscience, Karolinska Hospital, Stockholm, Sweden
To explore the etiology and pathophysiology
of schizophrenia, the HUBIN project – Human Brain Informatics
Center – has been established at the Karolinska Institute.
This study combines molecular genetic, psychiatric,
physical, brain imaging and perinatal risk data in a relational
database. Major HUBIN studies are conducted on a large Swedish national
sib pair material of schizophrenia and on a case - control material
of patients with schizophrenia. Data on more than 2000 clinical
and biological variables from more than 1000 subjects have been
entered into the database. Data mining procedures are used to search
for relations between variables from patients and volunteers.
The data will be used to classify subgroups
within the schizophrenia materials, and reveal new information regarding
genetic and environmental mechanisms for the etiology and pathophysiology
in the group of schizophrenia patients.
The database will also be used for a detailed
characterization of the variability of a large number of entities
of importance for the human brain and its functions in relation
to health and psychiatric disorders.
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