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Göran Sedvall seminar abstract
The Swedish HUBIN Project on Schizophrenia
G. Sedvall1, R. Adolfsson2, I. Agartz1, S.
Arnborg3, B. Ekholm1, H. Hall1, E. Jönsson1, T.F. McNeil4,
G. Okugawa5, U. Ösby1, M.J. Owen6, L. Terenius1
1Karolinska Institutet, Department of
Clinical Neuroscience, Karolinska Hospital, Stockolm, Sweden; 2Department
of Psychiatry, Umeå University Hospital, Umeå; 3NADA,
KTH, Stockholm; 4Department of Epidemiology, Malmö University
Hospital, Sweden; 5Department of Neuropsychiatry; 5Kansai Medical
University, Osaka, Japan, 6UWCM, Department of Psychological Medicine,
Cardiff, Wales, UK
The HUBIN (Human Brain Informatics) project
is a national interdisciplinary collaborative effort to explore
etiology and patophysiology in Swedish patients with schizophrenia.
Two different subject materials are used
in this approach. The first is a case-control
material of subjects from the Stockholm area. The second is a unique
Swedish material of sib-pairs with schizophrenia.
Standard electronic protocols are used to
determine, (1) perinatal risk factors from birth records, (2) phenoitypic
characteristics of the disorder, (3) quantitative structural MRI
brain volumes and (4) DNA characteristics from blood samples.
Currently about 400 case-controls and 150
out of 700 potential sib-pair families have been investigated. Coded
data are transferred to an IBM DB2 realtional database suitable
for multivariate and data mining exercises.
Preliminary analyses of data indicate relationships
between diagnosis and genes regulationg monoaminergic pathways and
specific chromosomal regions.
MRI data indicate possible subgroups among
patients with schizophrenia and reductions of white and gray cerebral
volumes and vermian lobules.
When further expanded, the HUBIN database
will allow the validation of previous and new hypotheses concerning
etiopathological aberrations among patients with schizophrenia.
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