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Katarina Varnäs poster abstract
Autoradiographic localisation of 5-HT
receptors in the human brain
Varnäs K., Hall H., Halldin C., Sedvall
G.
Department of Clinical Neuroscience, Psychiatry
Section, Karolinska Hospital, Stockholm, Sweden
The serotonin (5-HT) system is widely distributed
throughout the brain and is a target for the pharmacological treatment
of several psychiatric disorders. A detailed characterization of
5-HT receptor distribution in the human brain could be important
for the development of specific psychoactive drugs.
This presentation compares the distribution
of a number of 5-HT receptors and the 5-HT transporter (SERT) in
the human postmortem brain. Anatomically adjacent whole hemisphere
sections were incubated with specific radioligands for the 5-HT1A,
5-HT1B, 5-HT2A, 5-HT4 receptors and SERT. A detailed comparison
of the autoradiograms revealed different laminar and regional distribution
patterns in the neocortex, where 5-HT1A and 5-HT4 receptor binding
showed highest densities in superficial layers and 5-HT2A receptor
binding was most prominent in medial layers. The layering was less
distinct for 5-HT1B and SERT, although regional differences were
revealed with dense binding in the medial occipital cortex (5-HT1B)
and cingulate gyrus (SERT). Subregional differences between the
different receptors were also observed in the hippocampal formation
and in the basal ganglia.
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