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Drugs with reserpine changed the psychiatric care

rauwolfia serpentinaThe picture shows the plant Rauwolfia serpentina.

The greatest revolution within psychiatric care took place when a new efficacious drug against psychosis was synthesized, at the same time as an old Indian nature-cure medicine was rediscovered. In India the pulverized roots from the bush Rauwolfia serpentina have been utilized as a drug for a few thousands of years. Gradually Indian doctors discovered that this plant was especially active against psychotic anxiety and hypertension. In the sixteenth century the German botanist and doctor Leonard Rauwolf brought the medicine to Europe. There it was utilized to a varying degree but was forgotten in the end of the nineteenth century. Not until well into the twentieth century the Indian doctors succeeds in making Western scientist interested in the medical plant, because of its capability to reduce hypertension. In 1952 Swiss researchers analyze the roots and discover that the active substance is reserpine. When the doctors began to utilize reserpine against hypertension they found that this substance had a good effect in psychotic patients. The patients became calmer and started to function socially again. Unfortunately, though, some of them became depressed.

 

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© HUBIN updated September 26, 2002 .

Håkan Hall and Ulrika Kahl at Human Brain Informatics
Department of Clinical Neuroscience, Psychiatry Section
Karolinska Institutet, SE-171 76 Stockholm, SWEDEN.
Phone: +46-8-517 75651 Fax: +46-8-34 65 63 E-mail: info@hubin.org