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Selection of Articles from Medline (09/13/01)
Infectious
and immune factors in the pathogenesis of neurodevelopmental disorders:
Epidemiology, hypotheses, and animal models.
By Hornig M. & Lipkin W.I., in Ment Retard Dev Disabil Res
Rev. 7(3):200-210, 2001. Review.
Summary: Infectious and immune factors may contribute to
the pathogenesis of neurodevelopmental disorders like autism, mental
retardation and schizophrenia. Animal models of neurodevelopmental
disorders based upon viral infection can be used to identify the
neural processes that are involved.
The
NISAD Schizophrenia Research Register: why do we need a database
of schizophrenia volunteers?
By Loughland C.M., Carr V.J. & Lewin T.J., in Aust N Z J
Psychiatry. 35(5):660-667, 2001.
Summary: Databases (like HUBIN's) for data from clinical
studies and research provides a unique and invaluable resource,
as well as a complementary recruitment source for researchers who
would otherwise rely on samples drawn primarily from mental health
services.
Relationship
between Cannabis Use, Schizotypal Traits, and Cognitive Function
in Healthy Subjects.
By Mass R., Bardong C., Kindl K. & Dahme B., in Psychopathology.
34(4):209-214, 2001.
Summary: Among cannabis users there is an increased number
of subjects with schizotypal features, and schizotypal subjects
appear more likely to use cannabis than the general population.
Hence, cannabis use may be a vulnerability indicator for schizophrenia.
The
influence of familial loading on the course of schizophrenic symptoms
and the success of psychoeducational therapy.
By Feldmann R., Hornung W.P., Buchkremer G. & Arolt V., in Psychopathology.
34(4):192-197, 2001.
Summary: Familial loading contributes substantially to a
high rehospitalization rate and a poor outcome in schizophrenic
patients. How do one do to arrest this unfavorable development.
Linked
polymorphisms (-333G>T and -286A>G) in the promoter region of the
CCK-A receptor gene may be associated with schizophrenia.
By Tachikawa H., Harada S., Kawanishi Y., Okubo T. & Suzuki
T., in Psychiatry Res. 103(2-3):147-155, 2001.
Summary: In addition to polymorphisms reported previously
in the gene for the cholecystokinin A receptor (CCKAR), two novel
polymorphisms were identified. This suggests the possible involvement
of the -333G>T and the -286A>G polymorphisms in the promoter region
of the CCKAR gene in the predisposition to schizophrenia.
Environmental
animal models for sensorimotor gating deficiencies in schizophrenia:
a review.
By Weiss I.C. & Feldon J., in Psychopharmacology (Berl).
156(2-3):305-326, 2001. Review.
Summary: Animal models for social behaviour offer the advantage
of avoiding invasive manipulations, which allows for a variety of
anatomical, electrophysiological, neuroendocrine or neurochemical
investigations in the absence of confounding pharmacological or
surgical effects.
Dopamine
receptor polymorphisms and drug response in schizophrenia.
By Scharfetter J., in Pharmacogenomics. 2(3):251-261, 2001.
Review.
Summary: This review will focus on the dopamine receptor
genes which have, based on the dopamine hypothesis of schizophrenia,
been a prime target in pharmacogenetic studies of schizophrenia.
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