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Elevation of prolactin

woman_with_fractureSome antipsychotic medications increase the secretion of the hormone prolactin in the body.

Prolactin is essential in the induction of lactation in mammals, i.e. it is the hormone that controls the production of milk in women. Elevated prolactin levels may therefor result in milk in the breasts, even though the woman not recently have been pregnant and given birth.

Also prolactin is "synergistic with estrogen", which is another female sex hormone. As a result, female patients may experience a suppression or absence of menses. Also, the interest for sex may be affected for both female and male patients.

High prolactin levels may cause osteoporosis in older patients. Osteoporosis is a reduction of bone mass, which may lead to fractures.

 

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© HUBIN updated September 26, 2002 .

Håkan Hall and Ulrika Kahl at Human Brain Informatics
Department of Clinical Neuroscience, Psychiatry Section
Karolinska Institutet, SE-171 76 Stockholm, SWEDEN.
Phone: +46-8-517 75651 Fax: +46-8-34 65 63 E-mail: info@hubin.org